Rosa Blasi's television debut was a recurring role on the CBS soap opera, The Bold and the Beautiful. Soon to follow was a starring role on the MTV/UPN sitcom Hitz. She soon found herself guest starring on numerous shows such as Frasier, Becker, Caroline in the City, The Drew Carey Show, Grown Up, Holding Ratchild, and Beverly Hills 90210. She later starred in the dramatic Showtime film, Noriega: God's Favorite, which was shot in Bratislava. The film was directed by Roger Spottiswoode and co-starred Bob Hoskins. The film was critically acclaimed. In her breakout role, Blasi starred in the Lifetime drama series Strong Medicine from 2000 to 2006, starring as an women's health specialist who runs a free health clinic. She made an appearance in "Shootout", a 2005 episode of CSI: Miami. Audiences saw Blasi in her first major film role as the wife of Bill Pullman's character in The Grudge.